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Virus infections remain a major threat to human and animal health. They have a huge impact on global economies and account for a substantial part of healthcare costs worldwide. RNA viruses are of particular interest because their replication machinery lacks proofreading activity, resulting in high numbers of nucleotide misincorporations during viral genome replication and the generation of viral "quasispecies", genetically diverse virus populations containing large numbers of variants that differ from one another in one or more position(s) of the genome sequence.
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